The Great Midwest Athletic Conference is a NCAA Division II athletic conference with full and future member institutions located in Indiana, Kentucky, Michigan, and Ohio. The conference, established in 2011, consists of 13 private, non-profit member institutions and sponsors 26 conference championship sport offerings.

Current full member institutions include Ashland University (OH), Cedarville University (OH), University of Findlay (OH), Hillsdale College (MI), Kentucky Wesleyan College (KY), Lake Erie College (OH), Malone University (OH), Northwood University (MI), Ohio Dominican University (OH), Thomas More University (KY), Tiffin University (OH), Ursuline College (OH), and Walsh University (OH), with the University of Indianapolis (IN) set to join in July of 2027.

The Conference also has six associate members in the sports of men's lacrosse, stunt, swimming & diving, and wrestling. Those institutions include Davis & Elkins College (WV), Davenport (MI), Point Park University (PA),Roberts Wesleyan (NY),Seton Hill University (PA) and Wheeling University (WV). 

The Conference, led by founding Commissioner Tom Daeger, is headquartered in downtown Indianapolis.